🫁 Structural Network Medicine — Pneumology

Why some drugs work, others don't — and topology explains the difference.

This explorer presents structural fragility analyses of 5 respiratory disease signaling networks, covering 21 approved drugs. Each drug's molecular targets are mapped to the network topology to determine whether they hit structurally irreplaceable interactions (always-fragile) or redundant ones (solidified).

The Fragility Index (FI) = fraction of always-fragile edges. Higher FI → more vulnerable network → monotherapy more likely to work.

🔬 Full analysis engine: cognitive-engineering.dev 📄 Method: Zenodo 10.5281/zenodo.19045028

The Structural Gradient Across Respiratory Diseases

NSCLC (50%) → Asthma (63%) → IPF (68%) → CF (80%) → COPD (94%)

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Want to analyze YOUR network?

This explorer shows pre-computed results for 5 respiratory diseases. To run structural analysis on your own signaling network:

👉 cognitive-engineering.dev — upload a network, get FI + criticality + liquefaction in minutes.

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